A comparison of depressive symptom profiles between current major depressive disorder and schizophrenia spectrum disorder

Depressive symptoms are highly prevalent and clinically relevant in schizophrenia spectrum disorder (SSD) patients. So far, little is known about to what extent the depressive symptom profile SSD comparable that seen major (MDD). Data were derived from Genetic Risk Outcome of Psychosis study (GROUP) Netherlands Study Depression Anxiety (NESDA). We examined differences severity profiles distribution mood/cognition somatic/vegetative using Quick Inventory Symptomatology - Self Report (QIDS-SR) within patients (n = 449), MDD 816) healthy controls 417), aged 18 50. Within SSD, associations between depression clinical demographic data examined. 60.4% showed substantial symptomatology (QIDS-SR?6). The difference was larger (higher MDD, effect size 1.13), than (effect 0.74). In with multivariable regression analyses lower social functioning, male gender, use benzodiazepine more severe positive associated higher overall symptomatology. antipsychotics or antidepressants symptoms. More half have considerable symptomatology, a relative preponderance compared MDD. Future research could explore whether may also be biological dysregulations like